AA amyloidosis associated with hepatitis B

Saha, Abhijeet
Theis, Jason D.
Vrana, Julie A.
Dubey, Nand K.
Batra, Vineeta V.
Sethi, Sanjeev

¹Division of Pediatric Nephrology, PGIMER & Associated Dr. RML Hospital, New Delhi, India
²Department of Laboratory Medicine and Pathology, Division of Anatomic Pathology, Mayo Clinic, Rochester, MN, USA
³Department of Pathology, GB Pant Hospital, New Delhi, India

Correspondence and offprint requests to: Sanjeev Sethi; E-mail: [email protected]

Received March 17, 2011

Accepted March 30, 2011

Nephrology Dialysis Transplantation 26(7):p 2407-2412, July 2011. | DOI: 10.1093/ndt/gfr224

We report a 13-year-old Indian boy with nephrotic syndrome caused by renal AA amyloidosis. Workup of the AA amyloidosis revealed chronic hepatitis B. Laser microdissection of the Congo-red-positive glomeruli and vessels followed by liquid chromatography and tandem mass spectrometry confirmed the presence of serum amyloid A (SAA) protein and ruled out hereditary and familial amyloidosis. Furthermore, mass spectrometry also detected a variant of SAA protein (SAA W71R).