Neonatal-Onset Multisystem Inflammatory Disease Responsive to Interleukin-1(beta) Inhibition

From the National Institute of Arthritis and Musculoskeletal and Skin Diseases (R.G.-M., N.J.D., S.W.C., A.G., J.J., I.A., T.H.P., C.S., D.L.K.), National Eye Institute (B.I.R.), National Institute on Deafness and Other Communication Disorders (H.J.K., C.B., C.Z.), National Institute of Neurological Disorders and Stroke (E.W., B.I.K.), Clinical Center (S.H., F.P., S.R.P., S.M.P., R.A.W., J.A.B.), National Cancer Institute (M.L.T.) National Institute of Allergy and Infectious Disease (M.H.H., S.M.H.), and National Institute of Diabetes and Digestive and Kidney Diseases (S.C.H.), National Institutes of Health, Bethesda, Md.; University of North Carolina, Chapel Hill (L.S.); University of Michigan, Ann Arbor (B.S.A.); Saint Louis University, St. Louis (T.L.M.); Children's Hospital, Boston (R.C.F.); Children's Hospital, Los Angeles (B.S.); University of Oklahoma College, Oklahoma City (J.N.J., K.O.); University of Minnesota, Minneapolis (R.K.V.); Children's Hospital and Regional Medical Center, Seattle (L.O.B.); University of Washington Bone and Joint Center, Seattle (G.G.); State University of New York Hospital, Syracuse (W.P.H.); Texas Children's Hospital Baylor College of Medicine, Houston (R.W.W.); Watauga Medical Center, Boone, N.C. (W.H.); Adult and Pediatric Rheumatology, San Antonio, Tex. (J.L.C.); and Royal Free University College Medical School, London (P.N.H.). Address reprint requests to Dr. Goldbach-Mansky at NIAMS, Bldg. 10, Rm. 9S-205, 10 Center Dr., Bethesda, MD 20892, or at [email protected].