From the National Children's Research Centre and Department of Paediatric Dermatology, Our Lady's Children's Hospital, and the Department of Clinical Medicine, Trinity College — both in Dublin (A.D.I.); the Division of Molecular Medicine, Colleges of Life Sciences and Medicine, Dentistry, and Nursing, University of Dundee, Dundee, United Kingdom (W.H.I.M.); the Department of Pediatrics, National Jewish Health, Denver (D.Y.M.L.); and the Department of Pediatrics, University of Colorado Denver, Aurora (D.Y.M.L.).
Address reprint requests to Dr. Leung at National Jewish Health, 1400 Jackson St. (K926i), Denver, CO 80206, or at [email protected].
Disclosure forms provided by the authors are available with the full text of this article at NEJM.org.
Drs. Irvine and McLean contributed equally to this article.
We thank the patients and families who have contributed so importantly to our studies, Boyd Jacobson for superb assistance with earlier versions of the figures, and Maureen Sandoval for assistance in preparation of an earlier draft of this manuscript.
