Antibody-Associated Reversal of ATTR Amyloidosis-Related Cardiomyopathy

Fontana, Marianna M.D., Ph.D.
Gilbertson, Janet M.Sc.
Verona, Guglielmo Ph.D.
Riefolo, Mattia M.D.
Slamova, Ivana Ph.D.
Leone, Ornella M.D.
Rowczenio, Dorota Ph.D.
Botcher, Nicola B.Sc.
Ioannou, Adam M.B., B.S.
Patel, Rishi K. M.B., B.S.
Razvi, Yousuf M.B., Ch.B.
Martinez-Naharro, Ana M.D., Ph.D.
Whelan, Carol J. M.D.
Venneri, Lucia M.D., Ph.D.
Duhlin, Amanda Ph.D.
Canetti, Diana Ph.D.
Ellmerich, Stephan Ph.D.
Moon, James C. M.D.
Kellman, Peter Ph.D.
Al-Shawi, Raya Ph.D.
McCoy, Laura Ph.D.
Simons, Paul J. Ph.D.
Hawkins, Philip N. Ph.D., F.Med.Sci.
Gillmore, Julian D. M.D., Ph.D.

²IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy
⁵University College London, London, United Kingdom
⁶National Institutes of Health, Bethesda, MD
⁷University College London, London, United Kingdom [email protected]

Supported by a British Heart Foundation Intermediate Clinical Research Fellowship (FS/18/21/33447, to Dr. Fontana), a Medical Research Council Career Development Award (MR/R008698/1, to Dr. McCoy), and a project grant from the British Heart Foundation (PG/16/76/32394, to Dr. Simons).

Disclosure forms provided by the authors are available with the full text of this letter at NEJM.org.

New England Journal of Medicine 388(23):p 2199-2201, June 8, 2023. | DOI: 10.1056/NEJMc2304584

Antibody-Associated Cardiac Amyloid Regression

The investigators describe antibodies that bound amyloid in three patients with transthyretin amyloidosis. Spontaneous regression of cardiomyopathy occurred in all three patients.