Protein-Losing Enteropathy

Ozen, Ahmet M.D.
Lenardo, Michael J. M.D.

From the Department of Pediatrics, Division of Allergy and Immunology, Marmara University, School of Medicine, the Istanbul Jeffrey Modell Diagnostic Center for Primary Immunodeficiency Diseases, and the Isil Berat Barlan Center for Translational Medicine — all in Istanbul, Turkey (A.O.); and the Molecular Development of the Immune System Section, Laboratory of Immune System Biology, Clinical Genomics Program, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD (M.J.L.).

Dr. Lenardo can be contacted at [email protected] or at the Molecular Development of the Immune System Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bldg. 10, Rm. 11D14, 10 Center Dr., Mail Stop Code 1892, Bethesda, MD 20892-1892.

Disclosure forms provided by the authors are available with the full text of this article at NEJM.org.

Dan L. Longo, M.D., Editor

New England Journal of Medicine 389(8):p 733-748, August 24, 2023. | DOI: 10.1056/NEJMra2301594

Protein-Losing Enteropathy

Loss of plasma proteins into the gastrointestinal tract may be due to capillary diffusion of proteins into the interstitium, epithelial permeability, or leakage and rupture of dilated lacteals.