Trigeminal neuralgia in multiple sclerosis relieved by a prostaglandin E analogue

Reder, Anthony T. MD
Arnason, Barry G.W. MD

From the Department of Neurology and the Brain Research Institute, University of Chicago, IL.
Supported in part by NIH (#5 PO1 NS 24575-03) (B.G.W.A. and A.T.R.) and by the Brain Research Fund (A.T.R.).
Received September 9, 1994. Accepted in final form October 25, 1994.
Address correspondence and reprint requests to Dr. Anthony T. Reder, Department of Neurology and the Brain Research Institute, MC 2030, University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637.

Neurology 45(6):p 1097-1098, June 1995.

Trigeminal neuralgia is an uncommon but troublesome symptom of multiple sclerosis that can be refractory to conventional treatments.Misoprostol, a long-acting prostaglandin E₁ analogue, relieved pain in six of seven patients who had failed to respond to conventional pharmacologic therapy.

NEUROLOGY 1995;45

1097-1100