Tenecteplase vs. Alteplase for Treatment of Acute Ischemic Stroke: It Is Time to Make the Change

Fink, Matthew E. MD

Neurology Alert 43(2):p 13-14, October 2023.

SOURCES: Bala F, Singh N, Buck B, et al. Safety and efficacy of tenecteplase compared with alteplase in patients with large vessel occlusion stroke: A prespecified secondary analysis of the ACT randomized clinical trial. JAMA Neurology 2023;80:824-832.

Warach SJ, Ranta A, Kim J, et al. Symptomatic intracranial hemorrhage with tenecteplase vs alteplase in patients with acute ischemic stroke: The Comparative Effectiveness of Routine Tenecteplase vs Alteplase in Acute Ischemic Stroke (CERTAIN) collaboration. JAMA Neurology 2023;80:732-738.