VBASE2, an integrative V gene database

Retter, Ida
Althaus, Hans Helmar
Münch, Richard
Müller, Werner

Department of Experimental Immunology, German Research Centre for Biotechnology, Mascheroder Weg 1, D-38124 Braunschweig, Germany
¹Institute for Genetics, University of Cologne, Weyertal 121, D-50931 Cologne, Germany
²Institute of Microbiology, Technical University Braunschweig, Spielmannstrasse 7, D-38106 Braunschweig, Germany

Received August 13, 2004; Revised and Accepted October 12, 2004

^*To whom correspondence should be addressed. Tel: +49 531 6181 687; Fax: +49 531 6181 444; Email: [email protected]

Present address: Hans Helmar Althaus, Science + Computing ag, Hagellocher Weg 71-75, D-72070 Tübingen, Germany

The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use permissions, please contact [email protected].

Nucleic Acids Research 33:p D671-D674, January 1, 2005.

The database VBASE2 provides germ-line sequences of human and mouse immunoglobulin variable (V) genes. It acts as an interconnecting platform between several existing self-contained data systems: VBASE2 integrates genome sequence data and links to the V genes in the Ensembl Genome Browser. For a single V gene sequence, all references to the EMBL nucleotide sequence database are provided, including references for V(D)J rearrangements. Furthermore, cross-references to the VBASE database, the IMGT database and the Kabat database are available. A DAS server allows the display of VBASE2 V genes within the Ensembl Genome Browser. VBASE2 can be accessed either by a web-based text query or by a sequence similarity search with the DNAPLOT software. VBASE2 is available at http://www.vbase2.org, and the DAS server is located at http://www.dnaplot.com/das.