The anaphase-promoting complex: a key factor in the regulation of cell cycle

Castro, Anna
Bernis, Cyril
Vigneron, Suzanne
Labbé, Jean-Claude
Lorca, Thierry

¹Centre de Recherche de Biochimie Macromoléculaire, CNRS FRE 2593 1919 Route de Mende, 34293 Montpellier cedex 5, France

Oncogene (2005) 24, 314-325. doi:10.1038/sj.onc.1207973

*Correspondence: T Lorca; E-mail: [email protected]; A Castro, [email protected]

Oncogene 24(3):p 314-325, January 13, 2005.

Events controlling cell division are governed by the degradation of different regulatory proteins by the ubiquitin-dependent pathway. In this pathway, the attachment of a polyubiquitin chain to a substrate by an ubiquitin-ligase targets this substrate for degradation by the 26S proteasome. Two different ubiquitin ligases play an important role in the cell cycle: the SCF (Skp1/Cullin/F-box) and the anaphase-promoting complex (APC). In this review, we describe the present knowledge about the APC. We pay particular attention to the latest results concerning APC structure, APC regulation and substrate recognition, and we discuss the implication of these findings in the understanding the APC function.