HuR: Post-Transcriptional Paths to Malignancy

de Silanes, Isabel López
Lal, Ashish
Gorospe, Myriam

Laboratory of Cellular and Molecular Biology; National Institute on Aging-Intramural Research Program; National Institutes of Health; Baltimore, Maryland USA

^*Correspondence to: Myriam Gorospe; Box 12, LCMB, NIA-IRP, NIH; 5600 Nathan Shock Dr.; Baltimore, Maryland 21224 USA; Tel: 410.558.8443; Fax: 410.558.8386; Email: [email protected]

Accepted 01/19/04

This manuscript has been published online as a RNA Biology E-publication: http://www.landesbioscience.com/journals/rnabiology/abstract.php?id=1552

ACKNOWLEDGEMENTS We are grateful to D.L. Longo, S.C. Cunningham, and P.J. Morin for enlightening discussions on this topic.

RNA Biology 2(1):p e11-e13, January-February-March 2005.

ABSTRACT

The RNA-binding protein HuR regulates the stability and translation of target mRNAs. While no HuR mutations have been found in cancer, a link between HuR and malignant transformation has been suggested in cancers of the breast, colon, lung, and ovary. We describe a paradigm consistent with a central role of HuR in oncogenesis.