Miller Fisher's Syndrome

Teener, James W. MD

¹Department of Neurology, University of Michigan Health System, Ann Arbor, Michigan

Address for correspondence James W. Teener, MD, Department of Neurology, University of Michigan Health System, 1C327 UH EMG LAB SPC 5036, 1500 E. Medical Center Dr., Ann Arbor, MI 48109-5036, e-mail: [email protected]

Seminars in Neurology 32(5):p 512-516, November 2012. | DOI: 10.1055/s-0033-1334470

Abstract

Miller Fisher's syndrome is a rare variant of Guillain-Barré's syndrome characterized by the acute development of ataxia, ophthalmoparesis, and areflexia. Most patients have a measureable antibody in serum directed against the GQ1b ganglioside. This antibody is also present in the serum of patients with other forms of Guillain-Barré's syndrome who have prominent ataxia or ophthalmoplegia as part of their clinical presentation. Miller Fisher's syndrome generally is self-limited and has an excellent prognosis.